Am J Psychiatry 156:891-896, June 1999
© 1999 American Psychiatric Association
Hypofrontality in Attention Deficit Hyperactivity Disorder During Higher-Order Motor Control: A Study With Functional MRI
Katya Rubia, Ph.D.,
Stephan Overmeyer, M.D.,
Eric Taylor, M.D.,
Michael Brammer, Ph.D.,
Steve C.R. Williams, Ph.D.,
Andrew Simmons, Ph.D., and
Edward T. Bullmore, Ph.D.
OBJECTIVE: Functional magnetic resonance imaging (MRI) was used to investigate the hypothesis that attention deficit hyperactivity disorder (ADHD) is associated with a dysfunction of prefrontal brain regions during motor response inhibition and motor timing. METHOD: Generic brain activation of seven adolescent boys with ADHD was compared to that of nine comparison subjects equivalent in sex, age, and IQ while they were performing a stop task, requiring inhibition of a planned motor response, and a motor timing task, requiring timing of a motor response to a sensory cue. RESULTS: The hyperactive adolescents showed lower power of response in the right mesial prefrontal cortex during both tasks and in the right inferior prefrontal cortex and left caudate during the stop task. CONCLUSIONS: ADHD is associated with subnormal activation of the prefrontal systems responsible for higher-order motor control. Functional MRI is a feasible technique for investigation of neural correlates of ADHD.
This article has been cited by other articles:
|
|
|
|
 
K. Rubia, R. Halari, A. Christakou, and E. Taylor
Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate
Phil Trans R Soc B,
July 12, 2009;
364(1525):
1919 - 1931.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Davis, L. A. Pass, W. H. Finch, R. S. Dean, and R. W. Woodcock
The Canonical Relationship Between Sensory-Motor Functioning and Cognitive Processing in Children with Attention-Deficit/Hyperactivity Disorder
Arch Clin Neuropsychol,
July 2, 2009;
(2009)
acp032v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Sigi Hale, S. K. Loo, E. Zaidel, G. Hanada, J. Macion, and S. L. Smalley
Rethinking a Right Hemisphere Deficit in ADHD
J Atten Disord,
July 1, 2009;
13(1):
3 - 17.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Bramham, F. Ambery, S. Young, R. Morris, A. Russell, K. Xenitidis, P. Asherson, and D. Murphy
Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation
Autism,
May 1, 2009;
13(3):
245 - 264.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. L. Galinanes, I. R. E. Taravini, and M. Gustavo Murer
Dopamine-Dependent Periadolescent Maturation of Corticostriatal Functional Connectivity in Mouse
J. Neurosci.,
February 25, 2009;
29(8):
2496 - 2509.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. McAlonan, V. Cheung, S. E. Chua, J. Oosterlaan, S.-f. Hung, C.-p. Tang, C.-c. Lee, S.-l. Kwong, T.-p. Ho, C. Cheung, et al.
Age-related grey matter volume correlates of response inhibition and shifting in attention-deficit hyperactivity disorder
The British Journal of Psychiatry,
February 1, 2009;
194(2):
123 - 129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Rubia, A. B. Smith, R. Halari, F. Matsukura, M. Mohammad, E. Taylor, and M. J. Brammer
Disorder-Specific Dissociation of Orbitofrontal Dysfunction in Boys With Pure Conduct Disorder During Reward and Ventrolateral Prefrontal Dysfunction in Boys With Pure ADHD During Sustained Attention
Am J Psychiatry,
January 1, 2009;
166(1):
83 - 94.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Padolsky
A Comparison of Cognitive and Psychosocial Function for Males Within the ADHD Continuum
Clinical Case Studies,
December 1, 2008;
7(6):
521 - 537.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. Gogtay, A. Lu, A. D. Leow, A. D. Klunder, A. D. Lee, A. Chavez, D. Greenstein, J. N. Giedd, A. W. Toga, J. L. Rapoport, et al.
Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
PNAS,
October 14, 2008;
105(41):
15979 - 15984.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Rubia, R. Halari, A. B. Smith, M. Mohammed, S. Scott, V. Giampietro, E. Taylor, and M. J. Brammer
Dissociated Functional Brain Abnormalities of Inhibition in Boys With Pure Conduct Disorder and in Boys With Pure Attention Deficit Hyperactivity Disorder
Am J Psychiatry,
July 1, 2008;
165(7):
889 - 897.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Bush, T. J. Spencer, J. Holmes, L. M. Shin, E. M. Valera, L. J. Seidman, N. Makris, C. Surman, M. Aleardi, E. Mick, et al.
Functional Magnetic Resonance Imaging of Methylphenidate and Placebo in Attention-Deficit/Hyperactivity Disorder During the Multi-Source Interference Task
Arch Gen Psychiatry,
January 1, 2008;
65(1):
102 - 114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Eagle, C. Baunez, D. M. Hutcheson, O. Lehmann, A. P. Shah, and T. W. Robbins
Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus
Cereb Cortex,
January 1, 2008;
18(1):
178 - 188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J. P. Lerch, D. Greenstein, L. Clasen, A. Evans, J. Giedd, and J. L. Rapoport
From the Cover: Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
PNAS,
December 4, 2007;
104(49):
19649 - 19654.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Menzies, S. Achard, S. R. Chamberlain, N. Fineberg, C.-H. Chen, N. del Campo, B. J. Sahakian, T. W. Robbins, and E. Bullmore
Neurocognitive endophenotypes of obsessive-compulsive disorder
Brain,
December 1, 2007;
130(12):
3223 - 3236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Stevens, G. D. Pearlson, and K. A. Kiehl
An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder
Am J Psychiatry,
November 1, 2007;
164(11):
1737 - 1749.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J Frank, A. Scheres, and S. J Sherman
Understanding decision-making deficits in neurological conditions: insights from models of natural action selection
Phil Trans R Soc B,
September 29, 2007;
362(1485):
1641 - 1654.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. G. Almeida Montes, A. O. Hernandez Garcia, and J. Ricardo-Garcell
ADHD Prevalence in Adult Outpatients With Nonpsychotic Psychiatric Illnesses
J Atten Disord,
September 1, 2007;
11(2):
150 - 156.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Sigi Hale, S. Bookheimer, J. J. McGough, J. M. Phillips, and J. T. McCracken
Atypical Brain Activation During Simple & Complex Levels of Processing in Adult ADHD: An fMRI Study
J Atten Disord,
September 1, 2007;
11(2):
125 - 139.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Mark Mahone, M. Cristine Prahme, K. Ruble, S. H. Mostofsky, and C. L. Schwartz
Motor and Perceptual Timing Deficits Among Survivors of Childhood Leukemia
J. Pediatr. Psychol.,
September 1, 2007;
32(8):
918 - 925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Makris, J. Biederman, E. M. Valera, G. Bush, J. Kaiser, D. N. Kennedy, V. S. Caviness, S. V. Faraone, and L. J. Seidman
Cortical Thinning of the Attention and Executive Function Networks in Adults with Attention-Deficit/Hyperactivity Disorder
Cereb Cortex,
June 1, 2007;
17(6):
1364 - 1375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wang, T. Jiang, Q. Cao, and Y. Wang
Characterizing Anatomic Differences in Boys with Attention-Deficit/Hyperactivity Disorder with the Use of Deformation-Based Morphometry
AJNR Am. J. Neuroradiol.,
March 1, 2007;
28(3):
543 - 547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Leitner, G. M. Doniger, R. Barak, E. S. Simon, and J. M. Hausdorff
A Novel Multidomain Computerized Cognitive Assessment for Attention-Deficit Hyperactivity Disorder: Evidence for Widespread and Circumscribed Cognitive Deficits
J Child Neurol,
March 1, 2007;
22(3):
264 - 276.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. B. Smith, E. Taylor, M. Brammer, B. Toone, and K. Rubia
Task-Specific Hypoactivation in Prefrontal and Temporoparietal Brain Regions During Motor Inhibition and Task Switching in Medication-Naive Children and Adolescents With Attention Deficit Hyperactivity Disorder
Am J Psychiatry,
June 1, 2006;
163(6):
1044 - 1051.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Pliszka, D. C. Glahn, M. Semrud-Clikeman, C. Franklin, R. Perez III, J. Xiong, and M. Liotti,
Neuroimaging of Inhibitory Control Areas in Children With Attention Deficit Hyperactivity Disorder Who Were Treatment Naive or in Long-Term Treatment
Am J Psychiatry,
June 1, 2006;
163(6):
1052 - 1060.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Coxon, C. M. Stinear, and W. D. Byblow
Intracortical Inhibition During Volitional Inhibition of Prepared Action
J Neurophysiol,
June 1, 2006;
95(6):
3371 - 3383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Shaw, J. Lerch, D. Greenstein, W. Sharp, L. Clasen, A. Evans, J. Giedd, F. X. Castellanos, and J. Rapoport
Longitudinal Mapping of Cortical Thickness and Clinical Outcome in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder.
Arch Gen Psychiatry,
May 1, 2006;
63(5):
540 - 549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Liston, R. Watts, N. Tottenham, M. C. Davidson, S. Niogi, A. M. Ulug, and B.J. Casey
Frontostriatal Microstructure Modulates Efficient Recruitment of Cognitive Control
Cereb Cortex,
April 1, 2006;
16(4):
553 - 560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Vaidya, S. A. Bunge, N. M. Dudukovic, C. A. Zalecki, G. R. Elliott, and J. D.E. Gabrieli
Altered Neural Substrates of Cognitive Control in Childhood ADHD: Evidence From Functional Magnetic Resonance Imaging
Am J Psychiatry,
September 1, 2005;
162(9):
1605 - 1613.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Silk, A. Vance, N. Rinehart, G. Egan, M. O'Boyle, J. L. Bradshaw, and R. Cunnington
Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: functional magnetic resonance imaging study
The British Journal of Psychiatry,
September 1, 2005;
187(3):
282 - 283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Rubia, A. B. Smith, M. J. Brammer, B. Toone, and E. Taylor
Abnormal Brain Activation During Inhibition and Error Detection in Medication-Naive Adolescents With ADHD
Am J Psychiatry,
June 1, 2005;
162(6):
1067 - 1075.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Schachar, J. Crosbie, C. L. Barr, T. J. Ornstein, J. Kennedy, M. Malone, W. Roberts, A. Ickowicz, R. Tannock, S. Chen, et al.
Inhibition of Motor Responses in Siblings Concordant and Discordant for Attention Deficit Hyperactivity Disorder
Am J Psychiatry,
June 1, 2005;
162(6):
1076 - 1082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Shafritz, K. E. Marchione, J. C. Gore, S. E. Shaywitz, and B. A. Shaywitz
The Effects of Methylphenidate on Neural Systems of Attention in Attention Deficit Hyperactivity Disorder
Am J Psychiatry,
November 1, 2004;
161(11):
1990 - 1997.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Harrison, R. Manocha, and K. Rubia
Sahaja Yoga Meditation as a Family Treatment Programme for Children with Attention Deficit-Hyperactivity Disorder
Clinical Child Psychology and Psychiatry,
October 1, 2004;
9(4):
479 - 497.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. P. Schulz, J. Fan, C. Y. Tang, J. H. Newcorn, M. S. Buchsbaum, A. M. Cheung, and J. M. Halperin
Response Inhibition in Adolescents Diagnosed With Attention Deficit Hyperactivity Disorder During Childhood: An Event-Related fMRI Study
Am J Psychiatry,
September 1, 2004;
161(9):
1650 - 1657.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Grabli, K. McCairn, E. C. Hirsch, Y. Agid, J. Feger, C. Francois, and L. Tremblay
Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural study
Brain,
September 1, 2004;
127(9):
2039 - 2054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Aron, S. Monsell, B. J. Sahakian, and T. W. Robbins
A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex
Brain,
July 1, 2004;
127(7):
1561 - 1573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B Toone
Attention deficit hyperactivity disorder in adulthood
J. Neurol. Neurosurg. Psychiatry,
April 1, 2004;
75(4):
523 - 525.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lorberboym, N. Watemberg, A. Nissenkorn, B. Nir, and T. Lerman-Sagie
Technetium 99m Ethylcysteinate Dimer Single-Photon Emission Computed Tomography (SPECT) During Intellectual Stress Test in Children and Adolescents With Pure Versus Comorbid Attention-Deficit Hyperactivity Disorder (ADHD)
J Child Neurol,
February 1, 2004;
19(2):
91 - 96.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. Courvoisie, S. R. Hooper, C. Fine, L. Kwock, and M. Castillo
Neurometabolic Functioning and Neuropsychological Correlates in Children With ADHD-H: Preliminary Findings
J Neuropsychiatry Clin Neurosci,
February 1, 2004;
16(1):
63 - 69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. P. Munoz, I. T. Armstrong, K. A. Hampton, and K. D. Moore
Altered Control of Visual Fixation and Saccadic Eye Movements in Attention-Deficit Hyperactivity Disorder
J Neurophysiol,
July 1, 2003;
90(1):
503 - 514.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. X. Castellanos, P. P. Lee, W. Sharp, N. O. Jeffries, D. K. Greenstein, L. S. Clasen, J. D. Blumenthal, R. S. James, C. L. Ebens, J. M. Walter, et al.
Developmental Trajectories of Brain Volume Abnormalities in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
JAMA,
October 9, 2002;
288(14):
1740 - 1748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. R. DeLong
Mid-gestation right basal ganglia lesion: Clinical observations in two children
Neurology,
July 9, 2002;
59(1):
54 - 58.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Crosbie and R. Schachar
Deficient Inhibition as a Marker for Familial ADHD
Am J Psychiatry,
November 1, 2001;
158(11):
1884 - 1890.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Barbelivien, S. Ruotsalainen, and J. Sirvio
Metabolic Alterations in the Prefrontal and Cingulate Cortices are Related to Behavioral Deficits in a Rodent Model of Attention-deficit Hyperactivity Disorder
Cereb Cortex,
November 1, 2001;
11(11):
1056 - 1063.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Lane and R. L. Potter
Functional Neuroanatomy of Psychiatric Disorders: A Didactic Course for Residents
Acad Psychiatry,
September 1, 2001;
25(3):
148 - 155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. RUBIA, E. TAYLOR, A. B. SMITH, H. OKSANNEN, S. OVERMEYER, and S. NEWMAN
Neuropsychological analyses of impulsiveness in childhood hyperactivity
The British Journal of Psychiatry,
August 1, 2001;
179(2):
138 - 143.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. X. Castellanos, J. N. Giedd, P. C. Berquin, J. M. Walter, W. Sharp, T. Tran, A. C. Vaituzis, J. D. Blumenthal, J. Nelson, T. M. Bastain, et al.
Quantitative Brain Magnetic Resonance Imaging in Girls With Attention-Deficit/Hyperactivity Disorder
Arch Gen Psychiatry,
March 1, 2001;
58(3):
289 - 295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Santosh
Current topic: Neuroimaging in child and adolescent psychiatric disorders
Arch. Dis. Child.,
May 1, 2000;
82(5):
412 - 419.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Hypofrontality in Adolescent ADHD
Journal Watch Psychiatry,
August 1, 1999;
1999(801):
8 - 8.
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1999
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
