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Am J Psychiatry 1986; 143:300-305
Copyright © 1986 by American Psychiatric Association
Cortisol and Alzheimer's disease, I: Basal studies
KL Davis, BM Davis, BS Greenwald, RC Mohs, AA Mathe, CA Johns and TB Horvath
Patients with Alzheimer's disease and nondemented elderly control subjects
participated in studies of cortisol secretion during sleep and at 9:00 a.m.
and were given dexamethasone suppression tests (DSTs) and lumbar punctures.
Nocturnal and 9:00 a.m. cortisol concentrations were significantly higher
in the demented patients. CSF MHPG negatively correlated with mean
nocturnal cortisol. The most severely demented patients had the highest
9:00 a.m. and mean nocturnal cortisol concentrations. DST results did not
distinguish samples with substantially different nocturnal cortisol
concentrations. These results suggest that measurements of basal plasma
cortisol concentrations and dexamethasone suppression provide different
information but support the notion of somewhat higher than normal cortisol
concentrations in Alzheimer's disease patients.
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